ABSTRACT
@#Objective To discuss the effect of Cabrol in treatment of Stanford type A aortic dissection. Methods The clinical data of patients whom were diagnosed with type A aortic dissection of Stanford in our hospital from January 2013 to January 2018 were retrospectively analyzed. All of 40 patients underwent Cabrol surgical procedure. There were 31 males and 9 females aged 26–75 (48.8±3.3) years. The surgical treatment effect of the patients was evaluated, mainly including the aortic index, the changes in cardiac function before and after operation, and the postoperative follow-up. Results All the 40 patients completed the operation successfully. The diameter of ascending aorta and aortic sinus in postoperative patients were smaller than those before operation (P<0.05). Postoperative left ventricular ejection fraction and cardiac output increased, central venous pressure and left ventricular end-diastolic dimension decreased, and cardiac function indexes were significantly different from those before the operation (P<0.05). Seven patients suffered complications in postoperative follow-up including one stenting leakage, three neurological diseases and three acute renal failure. Two patients died postoperatively. Conclusion Cabrol’s operation is effective in the treatment of Stanford type A aortic dissection, which can significantly improve the cardiac function of patients, simplify the anastomosis of coronary artery ostia and decrease amount of bleeding.
ABSTRACT
Myeloperoxidase (MPO) is released from activated neutrophils.The inflammation in preeclampsia was found to be associated with endothelial dysfunction.We hypothesized that cardiac and circulating MPO levels are elevated in hypertensive pregnancy.Systolic and diastolic blood pressure and heart rate were measured on pregnancy days 14,16,18 and 20 in normal pregnant and hypertensive pregnant rats.Left and right ventricle weights,the number of viable fetuses,litter size,fetal and placenta weights were recorded on gestational day 21.Circulating and cardiac MPO activities,soluble fms-like tyrosine kinase-1 (sFlt-1) and vascular endothelial growth factor (VEGF) and nitric oxide (NO) were detected.The results showed increases in cardiac (left,but not right ventricle) and circulating MPO activities,and concomitantly lower number of viable fetuses,litter size,and fetal and placenta weights,and decreases in NO in hypertensive pregnant rats.Also,the increases in circulating sFlt-1 and VEGF were found in hypertensive pregnant group.In conclusion,maternal and fetal detrimental changes along with increases in circulating sFlt-1 and VEGF in hypertensive pregnancy may be associated with increases in cardiac and circulating MPO activities,confirming the causative role of inflammatory response in preeclampsia.
ABSTRACT
To establish a murine carotid artery transplantation model for the study of the chronic re-jection,80 rats were divided into two groups,an allotransplant (ACI-Lewis) group and an isotrans-plant (Lewis-Lewis) group (control group).The donor carotid artery and the recipient carotid artery were anastomosed by using a polyethylene cuff (internal diameter:0.7 mm,length:3 mm).The pathological changes of carotid artery transplant were observed 14,28 and 56 days after the trans-plantation.The results showed that the model was successfully established in 95% of the animals.The chronic rejection-associated arteriosclerosis was induced 28 days after the transplantation.The new chronic rejection model of carotid artery by using cuff technique caused fewer traumas and was easy to make.The pathological changes of the transplant mimicked the chronic rejection-associated arteriosclerosis found in human transplant.
ABSTRACT
The inhibitory effect of astilbin on transplant arteriosclerosis in murine model of thoracic aorta transplantation was examined.Model of rat thoracic aorta transplantation was established.Ninety rats were divided into three groups.In isograft group,the thoracic aorta of Brown Norway (BN) rat was anastomosed with the abdominal aorta of another BN rat.In allograft group,the thoracic aorta of BN rat was anastomosed with the abdominal aorta of Lewis rat.In astilbin group,the rats receiving allo-transplantation were given astiibin 5 mg/kg per day for a time of 28 days.The donor thoracic aorta and the recipient abdominal aorta were anastomosed by means of a polyethylene cannula (inner diameter:1.5 mm,length:3 mm length).The grafts were histologically examined for structural changes.The areas of arterial lumen and endatrium were calculated.Our results showed that,in the allograft group,28 days after aliografting,conspicuous proliferation of smooth muscles and infiltration with a great number of inflammatory cells were found in the tunica intima and tunica media.Astilbin significantly inhibited the proliferation of smooth muscles and ameliorated the infiltration of inflammatory cells thereyby prevent against the development of transplant arteriosclerosis.It is concluded that asltilbin can effectively prevent the development of arteriosclerosis in allotrausplant by inhibiting the proliferation of smooth muscles and inhibit the proliferation of smooth muscles in tunica of intima and media and reducing infiltration of the inflammatory cells.